{"id":20177,"date":"2023-06-26T11:57:09","date_gmt":"2023-06-26T09:57:09","guid":{"rendered":"https:\/\/nutritionalcoaching.com\/?p=20177"},"modified":"2023-06-26T11:57:09","modified_gmt":"2023-06-26T09:57:09","slug":"del-paracetamol-al-resveratrol","status":"publish","type":"post","link":"https:\/\/nutritionalcoaching.com\/en\/blog\/del-paracetamol-al-resveratrol\/","title":{"rendered":"Del paracetamol al resveratrol\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0"},"content":{"rendered":"

El paracetamol es, probablemente, el f\u00e1rmaco analg\u00e9sico m\u00e1s conocido hasta la fecha y el m\u00e1s consumido alrededor del mundo para paliar m\u00faltiples afecciones, muchas veces incluso tom\u00e1ndolo en contextos y dosis no adecuadas.<\/p>\n

Pese a que nos han hecho creer que el paracetamol es un f\u00e1rmaco completamente inocuo, esto deja de ser as\u00ed si la toma se extiende en el tiempo. Se han visto casos donde el paracetamol aumenta la presi\u00f3n arterial (Forman et al., 2005), agrava el riesgo de \u00falceras gastrointestinales (Rahme et al., 2008) y el riesgo de infarto de miocardio (Chan et al., 2006)<\/p>\n

Este f\u00e1rmaco (en dosis inadecuadas) es la primera causa de fallo hep\u00e1tico agudo en pa\u00edses como Estados Unidos, Reino Unido y los pa\u00edses escandinavos. En la comunidad europea, es la raz\u00f3n m\u00e1s prevalente de necesidad de trasplante de h\u00edgado por fallo hep\u00e1tico agudo.<\/p>\n

La toma de paracetamol extendida en el tiempo se ha vinculado tanto a la toxicidad hep\u00e1tica como a la renal. En poblaci\u00f3n m\u00e1s vulnerable como ni\u00f1os y mujeres embarazadas, los datos muestran una relaci\u00f3n entre la toma de paracetamol en mujeres embarazadas y una mayor probabilidad de que los ni\u00f1os sufran incidencia de asma, infertilidad en ni\u00f1os varones, peor desarrollo psicosocial \u00a0o trastorno de d\u00e9ficit de atenci\u00f3n.<\/p>\n

Parece ser que la mayor\u00eda de efectos negativos vinculados a la toxicidad del paracetamol est\u00e1n causados por compuesto producto de la metabolizaci\u00f3n del f\u00e1rmaco llamado NAPQI. Este, es altamente reactivo y peligroso para algunos tejidos del cuerpo. Cuando compuestos t\u00f3xicos como el NAPQI generan peligro a nuestros tejidos, la capacidad antioxidante del cuerpo es clave. Esta capacidad determina la velocidad con la que eliminamos los t\u00f3xicos de nuestro organismo.<\/p>\n

Nuestra capacidad antioxidante end\u00f3gena depende de un amplio complejo de enzimas y rutas metab\u00f3licas. Entre las prote\u00ednas antioxidantes m\u00e1s importantes podemos encontrar: el glutati\u00f3n, la super\u00f3xido dismutasa o la catalasa.<\/p>\n

Por tal de tratar de elevar la capacidad antioxidante end\u00f3gena del organismo, investigadores de todo el mundo estan en la b\u00fasqueda de cualquier tipo de mol\u00e9cula presente en alimentos o extractos herbales que al tomarla nos permita aumentar la capacidad de combatir contra los radicales libres. Estos radicales libres pueden generarse debido a factores como el ambiente, la comida ultraprocesada o, como hemos visto, los metabolitos de algunos f\u00e1rmacos.<\/p>\n

Una de estas mol\u00e9culas que se ha popularizado en los \u00faltimos a\u00f1os es el resveratrol. Este<\/span> es un polifenol natural perteneciente al grupo de los estilbenos. Lo podemos encontrar, principalmente, en la piel de la uva roja. El problema con el resveratrol es que aquel que ingerimos en forma de alimentos absorbe muy poco. Es por ello que se han formulado multitud de suplementos a base de resveratrol con cantidades mucho mayores de las que encontramos en alimentos.<\/div>\n

Entonces, cabe hacerse la pregunta: \u00bfTomar un suplemento de resveratrol vale la pena para combatir el estr\u00e9s oxidativo y \u201cdetoxificar nuestro cuerpo\u201d? Todav\u00eda es pronto para responder a esa pregunta de forma certera pero parte de la evidencia que tenemos disponible sobre el resveratrol y las prote\u00ednas antioxidantes que antes hemos nombrado nos dice que la toma del polifenol como suplemento no parece aumentar de forma significativa estas prote\u00ednas antioxidantes.<\/p>\n

Como conclusi\u00f3n, podemos decir que la inocuidad que nos han vendido con el uso del paracetamol para el tratamiento de todas las dolencias ha sido puesto en duda por la comunidad cient\u00edfica, encontrando correlaci\u00f3n entre da\u00f1o en h\u00edgado y ri\u00f1\u00f3n y un consumo inadecuado del f\u00e1rmaco alargado en el tiempo. Este da\u00f1o, entendido como toxicidad, involucra directamente a nuestro sistema antioxidante y este puede estar modulado por m\u00faltiples factores. Los suplementos de resveratrol se est\u00e1n comercializando precisamente con esa finalidad, sin embargo no existe suficiente evidencia de que la toma de estos suplementos sea efectiva a la hora de mejorar nuestra capacidad antioxidante.<\/p>\n

Cabe matizar que no estamos haciendo ning\u00fan tipo de recomendaci\u00f3n sobre el uso o no del paracetamol o los suplementos de resveratrol. Siempre se debe consultar con un profesional que tenga la formaci\u00f3n necesaria para asesorarte en base a tu caso individual.<\/p>\n

Para m\u00e1s informaci\u00f3n sobre nuestro servicio de nutrici\u00f3n ofrecido por expertos dietistas-nutricionistas no dudes en ponerte en contacto con nosotros en info@nutritionalcoaching.com<\/a>.<\/p>\n

\n

 <\/p>\n

Nutritional Coaching<\/a><\/p>\n

Institute Nutritional Coaching<\/a><\/p>\n

\u00a0<\/strong><\/p>\n

Bibliograf\u00eda<\/strong><\/p>\n

Brune K, Renner B, Tiegs G. Acetaminophen\/paracetamol: A history of errors, failures and false decisions: 130 Years of aniline analgesics. Eur J Pain. 2015; 19(7):953\u201365. PMID: 25429980.<\/p>\n

Koushki M, Lakzaei M, Khodabandehloo H, Hosseini H, Meshkani R, Panahi G. Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials. Postgrad Med J. 2020; 96(1134):197\u2013205. PMID: 31628212.<\/p>\n

Forman JP, Stampfer MJ, Curhan GC. Non-narcotic analgesic dose and risk of incident hypertension in US women. Hypertension. 2005;46(3):500\u20137.\u00a0 PMID: 16103274.<\/p>\n

Rahme E, Barkun A, Nedjar H, Gaugris S, Watson D. Hospitalizations for upper and lower GI events associated with traditional NSAIDs and acetaminophen among the elderly in Quebec, Canada. Am J Gastroenterol. 2008;103(4):872\u201382. PMID: 18371130.<\/p>\n

Chan AT, Manson JE, Albert CM, Chae CU, Rexrode KM, Curhan GC, et al. Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events. Circulation. 2006; 113(12):1578\u201387. PMID: 16534006.<\/p>\n

Marc Beato<\/p>\n

@nutreasier<\/p>","protected":false},"excerpt":{"rendered":"

El paracetamol es, probablemente, el f\u00e1rmaco analg\u00e9sico m\u00e1s conocido hasta la fecha y el m\u00e1s consumido alrededor del mundo para paliar m\u00faltiples afecciones, muchas veces incluso tom\u00e1ndolo en contextos y dosis no adecuadas. Pese a que nos han hecho creer que el paracetamol es un f\u00e1rmaco completamente inocuo, esto deja de ser as\u00ed si la […]<\/p>\n","protected":false},"author":8,"featured_media":20178,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"_joinchat":[],"footnotes":""},"categories":[31],"tags":[813,519],"class_list":["post-20177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-asesoramiento","tag-educacion-nutricional"],"yoast_head":"\nDel paracetamol al resveratrol\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 - Nutritional Coaching<\/title>\n<meta name=\"description\" content=\"Te explicamos todo sobre Del paracetamol al resveratrol\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 para que todo lo relacionado con blog est\u00e9 m\u00e1s presente en tu d\u00eda a d\u00eda.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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